ASTAXANTHIN AND HYPERTENSION
Carotenoid like astaxanthin can give us protection toward cardiovascular disease included hypertension. This condition related with blood vessel function disorder, contractible and rhythm change of blood vessel be mediated by relaxant substance (nitrate oxide NO; prostacycline) and constrictor factor (tromboxant; endothelin) in blood. More then, blood flow characteristic has importance function on pathologic complication that be viewed on atherosclerosis and coroner heart disease. Research that be presented here explain that astaxanthin can useful as part of an antioxidant therapy to reduce hypertension.
The result of research before that participate a carotenoid composition has been used to handle hypertension or high blood pressure. But Hussein et al., (2005a) publish the first research that participate astaxanthin with mouse spontaneous hypertension and stroke trend. This research investigates astaxanthin effect on blood pressure of aorta vessel which related with endothelium and nitrate oxide (NO) to explain mechanisms and response. Arterial blood pressure on mouse hypertension decrease approximately 10% when they are given astaxanthin 50 mg/kg/day for two weeks along. Giving for long period on mouse trend stroke show that by 5 mg/kg/day dose so has the same effect with 50 mg/kg/day. On Same time , on control group blood pressure increase until 8% at the five weeks. More next, astaxanthin hasn’t effect on normal blood pressure on mouse that healthy. The things that more interesting, author reported decrease 50% stroke incidence on trend stroke mouse which be given astaxanthin 50 mg/kg/day be compared with control group after 14 days.
Anti-hypertension mechanism by a part method can be explained from change of vascular reactivity and haemorheology. Micro-channel Array Flow Analysis (MC-FAN) measure a raising blood flow that significant amount 11% on a group that be given astaxanthin. Although plasma fluidity more be influenced by fibrinogen, on this researc, level of fibrinogen has not change and by that because, reparation of deformity and decreasing blood aggregation constitute the mechanism that probable. This matter be supported by Miyawaki et al., (2005) who so used MC-FAN to show reparation blood flow which significant in human who be given astaxanthin 6 mg for 10 days along. Sistematic investigation on relaxant response and constrictor show that astaxanthin can repair relaxation and sensitivity that depend on NO on constriction mechanisms. Astaxanthin reduce sensitivity toward angiotensin II (AngII) that be participated in blood vessel contraction, and bandaged ROS that usually prevent dilatation depending on Nitrate Oxide (NO) (Husein et al.,).
Therapy with Astaxanthin has so protect structural composition of wall structure of blood vessel. Hypertension usually causes process of thickening blood vessel wall that change rigidity and volume inside of blood vessel. So, reduce volume blood flow and increase pressure. Mouse which be given astaxanthin be protected from that structure changed and repair blood vessel wall until with ratio thickness lumen.
Although, that discovery from mouse spontaneous hypertension background, that matter constitute strong handling to make hypothesis longer on human clinical test.